Redline PL 20 #bmx #redline
Redline PL 20 #bmx #redline
More Posts from Fionaahutton and Others
Space man 🚀 never fails to be spaced out. 🍺🍾🥃🚬💊
This is so stupid but funny also. 💩
Moon Landing 1969
Brain cells that aid appetite control identified
It’s rare for scientists to get what they describe as “clean” results without spending a lot of time repeating the same experiment over and over again. But when researchers saw the mice they were working with doubling their weight within a month or two, they knew they were on to something.
“About twenty years ago there was a big step forward in our understanding of obesity when researchers discovered that our appetite is controlled by a key molecule called leptin. Leptin is a hormone which is produced by our fat cells, and is delivered by the blood to the brain to signal the brain that we are full and can stop eating,” explains Dr. Maia Kokoeva who is affiliated both with McGill University and the Research Institute of the McGill University Health Centre. “But even though receptors for leptin were discovered soon after in the hypothalamus, a brain area that regulates food intake and body weight, it has remained unclear how exactly leptin is detected.”
So about four years ago, Kokoeva and her team set out to explore which brain cells might play a role in the process of leptin sensing and weight gain. The answer, it turns out, lies in the median eminence.
“Protection” and “preservation” cells in a busy place
The median eminence is a brain structure at the base of the hypothalamus. It is a bit like a busy hub or market place through which hormones and molecules of various kinds travel in both directions between the brain and the bloodstream to ensure that the body functions smoothly.
The McGill research team has now discovered that without a particular group of cells (known as NG2-glia cells) in place in the median eminence, the leptin receptors in the brain never receive the messages from the body telling it that it is sated.
“Most of the brain is a well-protected fortress, designed to shelter delicate nerve cells,” says Kokoeva. “The median eminence is outside these protections, and so can be a dangerous environment for the nerve cells that detect leptin. We think that the NG2-glia cells act to support and shelter the leptin receptor neurons, enabling them to instruct the body when to stop eating.”
Crucial role of the median eminence in weight gain
“We developed an interest in NG2-glia cells in this specific part of the brain because unlike neurons, during much of our adult lives these cells are constantly dividing and they do so most actively in the median eminence,” says Tina Djogo, a McGill doctoral student and one of two lead authors on the study which was published in Cell Metabolism. “But though these cells were first described about thirty years ago it has been difficult so far to pinpoint their exact functions in the adult brain.”
Because of their particularly high turnover in the median eminence, the researchers wondered if the NG2-glia cells might play a role in leptin sensing and therefore in appetite control. So they used a drug to kill the NG2-glia cells in the median eminence of a group of mice and then watched to see whether there was a difference in food intake. The results were stunning.
Within three days after they started to receive the medication, some of the mice dubbed “gainers” had already started to eat more compared with the control group of mice who had not received medication. And by 30 days afterwards, the weight of some of the mice had doubled - from 25 grams to around 50 grams.
“But what was most exciting to us, was that even though NG2-glia are found across the brain” explains Sarah Robins, a research associate who was also a lead author on this study, “it was only when we removed these cells from the median eminence that we saw this clear increase in body weight.”
A possible explanation for weight gain in brain tumour patients
The researchers then corroborated the role of the NG2-glia cells in the median eminence in appetite control through experiments using genetically modified mice, and also by using irradiation. This latter discovery suggested an explanation for a previously unexplained phenomenon in human brain cancer survivors.
“People who have been treated for brain tumours using radiation to block cell proliferation often become overweight,” says Kokoeva. “However, there has never been any satisfactory explanation, but our experiments in mice now suggests that the reason for this weight gain may be the loss of NG2-glia in the median eminence as a result of radiation.”
The researchers are hopeful that the identification of NG2-glia in the median eminence as crucial elements in body weight and appetite control will pave the way to new targeted anti-obesity approaches directed towards maintaining or raising the NG2-glia population in the median eminence.
This is why foreigners find English so hard to learn properly.
Adjectives postpositive
If you heard your friend say, “Last night I ate a dinner delicious,” you would probably find that sentence a little odd. That’s because the adjective delicious is placed postpositively, meaning after the noun that it modifies. In English, the general rule is for adjectives to be prepositive, or placed before the nouns they modify. We say, “I had a good time,” and not “I had a time good.” But as is often the case in English grammar, there are plenty of exceptions to the rule.
One notable area of exception is in terms borrowed from Romance languages, where postpositive adjectives are common. We say professor emeritus, musician extraordinaire, steak flambé, chicken cacciatore, and pasta puttanesca.
Certain phrases in English that have become accepted as a unit feature postpositive adjectives, such as solicitor general and notary public. Compound nouns such as these typically pluralize by adding the plural ending to the base noun, not the adjective. That’s how we get solicitors general and notaries public.
English pronouns also tend to take adjectives postpositively. The box contained nothing useful. They wanted to see something beautiful.
Breaking the usual adjective/noun structure is sometimes done in poetry to aid meter or rhyme or for stylistic reasons. Think of the poem “Harlem” by Langston Hughes, in which he writes, “What happens to a dream deferred?” What a difference it would make to say, “What happens to a deferred dream?”
In the American Heritage Dictionary, if an adjective is commonly used postpositively, we typically show that by including illustrations or quotations after the definition.
Thank you for visiting the American Heritage Dictionary at ahdictionary.com!
A few stars above the California coast
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So this is the origins of
"Kilroy was here" ☺️
Kilroy Was Here!
He’s engraved in stone in the National World War II Memorial in Washington, DC – back in a small alcove where very few people have seen it. For the WWII generation, this will bring back memories. For younger folks, it’s a bit of trivia that is an intrinsic part of American history and legend.
Anyone born between 1913 to about 1950, is very familiar with Kilroy. No one knew why he was so well known….but everybody seemed to get into it. It was the fad of its time!
At the National World War II Memorial in Washington, DC
So who was Kilroy?
In 1946 the American Transit Association, through its radio program, “Speak to America,” sponsored a nationwide contest to find the real Kilroy….now a larger-than-life legend of just-ended World War II….offering a prize of a real trolley car to the person who could prove himself to be the genuine article.
Almost 40 men stepped forward to make that claim, but only James Kilroy from Halifax, Massachusetts, had credible and verifiable evidence of his identity.
“Kilroy” was a 46-year old shipyard worker during World War II (1941-1945) who worked as a quality assurance checker at the Fore River Shipyard in Quincy, Massachusetts (a major shipbuilder for the United States Navy for a century until the 1980s).
His job was to go around and check on the number of rivets completed. (Rivets held ships together before the advent of modern welding techniques.) Riveters were on piece work wages….so they got paid by the rivet. He would count a block of rivets and put a check mark in semi-waxed lumber chalk (similar to crayon), so the rivets wouldn’t be counted more than once.
A warship hull with rivets
When Kilroy went off duty, the riveters would surreptitiously erase the mark. Later, an off-shift inspector would come through and count the rivets a second time, resulting in double pay for the riveters!
One day Kilroy’s boss called him into his office. The foreman was upset about unusually high wages being “earned” by riveters, and asked him to investigate. It was then he realized what had been going on.
The tight spaces he had to crawl in to check the rivets didn’t lend themselves to lugging around a paint can and brush, so Kilroy decided to stick with the waxy chalk. He continued to put his check mark on each job he inspected, but added ”KILROY WAS HERE!“ in king-sized letters next to the check….and eventually added the sketch of the guy with the long nose peering over the fence….and that became part of the Kilroy message.
Kilroy’s original shipyard inspection “trademark” during World War II
Once he did that, the riveters stopped trying to wipe away his marks.
Ordinarily the rivets and chalk marks would have been covered up with paint. With World War II on in full swing, however, ships were leaving the Quincy Yard so fast that there wasn’t time to paint them. As a result, Kilroy’s inspection “trademark” was seen by thousands of servicemen who boarded the troopships the yard produced.
His message apparently rang a bell with the servicemen, because they picked it up and spread it all over the European and the Pacific war zones.
Before war’s end, “Kilroy” had been here, there, and everywhere on the long hauls to Berlin and Tokyo.
To the troops outbound in those ships, however, he was a complete mystery; all they knew for sure was that someone named Kilroy had “been there first.” As a joke, U.S. servicemen began placing the graffiti wherever they landed, claiming it was already there when they arrived.
As the World War II wore on, the legend grew. Underwater demolition teams routinely sneaked ashore on Japanese-held islands in the Pacific to map the terrain for coming invasions by U.S. troops (and thus, presumably, were the first GI’s there). On one occasion, however, they reported seeing enemy troops painting over the Kilroy logo!
Kilroy became the U.S. super-GI who had always “already been” wherever GIs went. It became a challenge to place the logo in the most unlikely places imaginable. (It is said to now be atop Mt. Everest, the Statue of Liberty, the underside of the Arc de Triomphe in Paris, and even scrawled in the dust on the moon by the American astronauts who walked there between 1969 and 1972.
In 1945, as World War II was ending, an outhouse was built for the exclusive use of Allied leaders Harry Truman, Joseph Stalin, and Winston Churchill at the Potsdam Conference. It’s first occupant was Stalin, who emerged and asked his aide (in Russian), “Who is Kilroy?”
To help prove his authenticity in 1946, James Kilroy brought along officials from the shipyard and some of the riveters. He won the trolley car….which he attached to the Kilroy home and used to provide living quarters for six of the family’s nine children….thereby solving what had become an acute housing crisis for the Kilroys.
The new addition to the Kilroy family home.
* * * *
And the tradition continues into the 21st century…
In 2011 outside the now-late-Osama Bin Laden’s hideaway house in Abbottabad, Pakistan….after the al-Qaida-terrorist was killed by U.S. Navy SEALs.
* * * *
A personal note….
My Dad’s trademark signature on cards, letters and notes to my sisters and I for the first 50 or so years of our lives (until we lost him to cancer) was to add the image of “Kilroy” at the end. We kids never ceased to get a thrill out of this….even as we evolved into adulthood.
To this day, the “Kilroy” image brings back a vivid image of my awesome Dad into my head….and my heart!
Dad: this one’s for you!
We FAILED as husbands... - Wife PC Build-Off Girls can build PCs.
