Rx Mnemonics

Me durning finals.

Some general resources:

Chemistry Glossary

Chemistry Exam Survival Guide

Toolbox – interactive graphing, tables, and calculators

Make virtual chemistry models

Interactive periodic table

Another site for making virtual chemistry models

Virtual labs – covers stoichiometry, thermochemistry, eq1uilibrium, acid base chemistry, solubility, oxidation/reduction and electrochemistry, analytical chemistry/lab techniques

Concept tests

Chemistry Science Fair Project Ideas

OChem Reaction Bank

Interactive chem simulations

Chemical calculations

The Chem Blog

Molecule of the day

Free chemistry drawing software

Laboratory Safety - Laboratory safety for the chemistry classroom

Periodic Table of Videos - Brady Haran

On this day in chemistry… - a history of chemistry

The faces of chemistry

Experimentation hub -  explore and enjoy our experiments to increase engagement in scientific investigation, develop new skills and enhance your knowledge.

Understanding journals - including reading articles, referencing, and example articles.

Resources for specific topics:

Stochiometry – the mole, molarity and density, reaction stoichiometry and limiting reagents, empirical formula and mixtures, gravimetric analysis

Themochemistry – energy and enthalpy, entropy

Kinetics – phenomenological and mechanistic kinetics

Equilibrium – LeChatlier’s principle, progress of reaction, equilibrium calculations, common ion effect

Acid base chemistry – strong acid and bases, weak acids and bases, buffer solutions, acid/base titrations

Solubility – solubility product, solubility and PH, common ion effect

Oxidation/Reduction and Electrochemistry – standard reduction potentials, galvanic cells

Analytical chemistry/ Lab techniques – reaction stoichiometry and limiting reagents, acid/base titrations, redox titrations, gravimetric analysis, UC/Vis spectroscopy

Physical chemistry – quantum mechanics, spectroscopy

Properties of solutions – intermolecular forces, colligative properties

Textbooks:

Chemistry Virtual Textbooks, Stephen Lower

Organic Chemistry, Tim Soderberg

Organic Chemistry I, George Mhehe

Environmental Chemistry, Dejene Tessema

Virtual Organic Chemistry

Industrial Chemistry, Helen Njenga

Inorganic Chemistry, Chrispin Kowenje

Physical Chemistry I, Onesmus Munyaki

General Chemistry, Principles, Patterns and Applications

Chemistry Books - a variety of chemistry textbooks

Chemistry Tutorials/Guides:

Atoms, Molecules, and Ions

Chemical reactions and stoichiometry

Electronic structure of atoms

Periodic table

Chemical bonds

Gases and kinetic molecular theory

State of matter and intermolecular forces

Chemical equilibrium

Acids and bases

Acid base equilibria and solubility equilibria

Thermodynamics

Redox reactions and electrochemistry

Kinetics

Nuclear chemistry

Organic Chemistry Tutorials/Guidelines:

Structure and bonding

Dot structures

Hybridization

Bond-line structures

Electronegativity

Resonance and acid base chemistry

Counting electrons

Resonance structures

Organic acid-base chemistry

Alkanes, cycloalkanes and functional groups

Naming alkanes

Naming alkanes, cycloalkanes, and bicyclic compounds

Conformations of alkanes

Conformations of cycloalkanes

Functional groups

Stereochemistry

Chirality

Enantiomers

Stereoisomeric relationships

Subsituation and elimination reactions

Free radical reaction

Sn1 vs Sn2

Nucleophilicity and basicity

Elimination reactions

Sn1/Sn2/E1/E2

Sn1 and Sn2

Alkenes and alkynes

Naming alkenes

Alkene reactions

Alkene nomenclature

Alkene reactions

Naming and preparing alkynes

Alkyne reactions

Alcohols, ethers, epoxides, sulphides

Alcohol nomenclature and properties

Synthesis of alcohols

Reactions of alcohols

Nomenclature and properties of ethers

Synthesis and cleavage of ethers

Nomenclature and preparation of epoxides

Conjugation, Diels-Alder, and MO theory

Addition reactions of conjugated dienes

Diels-Alder reaction

Molecular orbital theory

Aromatic compounds

Naming benzene derivatives

Reactions of benzene

Aromatic stability

Electrophilic aromatic substitution

Directing effects

Other reactions and synthesis

Aldehydes and ketones

Introduction to aldehydes and ketones

Reactions of aldehydes and ketones

Carboxylic acids and derivatives

Naming carboxylic acids

Formation of carboxylic acid derivatives

Nomenclature and reactions of carboxylic acids

Nomenclature and reactions of carboxylic acid derivatives

Alpha carbon chemistry

Formation of enolate anions

Aldol condensations

Amines

Naming amines

Spectroscopy

Infrared Spectroscopy

UV/Vis Spectroscopy

proton NMR

Careers:

A future in Chemistry

What can I do with my chemistry degree?

Chemistry Careers - American Chemical Society

What to do with a degree in chemistry - The Guardian

Antibodies (Human)

The ‘foot’ (bottom) of the antibody is known as the Fc fragment - binds to cells, binds to complement = effector function (kills or removes antigen)

The top (antigen binding) is the Fab fragment

Chains are held together with disulphide binds

Associated molecules allow intracellular signalling 

Normally 3X constant heavy chain domains per chain and a hinge region (except μ and ε which have 4 and no hinge region)

Classes of Immunoglobulins

The five primary classes of immunoglobulins are IgG, IgM, IgA, IgD and IgE,  distinguished by the type of heavy chain found in the molecule. 

IgG - gamma-chains

IgMs - mu-chains

IgAs - alpha-chains

IgEs - epsilon-chains

IgDs - delta-chains.

Differences in heavy chain polypeptides allow different types of immune responses. The differences are found primarily in the Fc fragment. There are only two main types of light chains: kappa (κ) and lambda (λ), and any antibody can have any combination of these 2 (variation).

IgG 

monomer

Gamma chains

70-85% of Ig in human serum. 

secondary immune response 

only class that can cross the placenta - protection of the newborn during first 6 months of life

principle antibody used in immunological research and clinical diagnostics

21 day half life

Hinge region (allows it to make Y and T shapes - increasing chance of being able to bind to more than one site)

Fc strongly binds to Fcγ receptor on phagocyte - opsono-phagocytosis

Activates complement pathway

IgM

Serum = pentamer 

Primary immune responses - first Ig to be synthesised

complement fixing 

10% of serum Ig 

also expressed on the plasma membrane of B lymphocytes as a monomer - B cell antigen receptor

H chains each contain an additional hydrophobic domain for anchoring in the membrane

Monomers are bound together by disulfide bonds and a joining (J) chain.

Each of the five monomers = two light chains (either kappa or lambda) and two mu heavy chains.

heavy chain = one variable and four constant regions (no hinge region)

can cause cell agglutination as a result of recognition of epitopes on invading microorganisms. This antibody-antigen immune complex is then destroyed by complement fixation or receptor mediated endocytosis by macrophages.

In humans there are four subclasses of IgG: IgG1, IgG2, IgG3 and IgG4. IgG1 and IgG3 activate complement.

IgD 

B cell receptor

<1% of blood serum Ig

has tail pieces that anchor it across B cell membrane

forms an antigen specific receptor on mature B cells - consequently has no known effector function (don’t kill antigens, purely a receptor) (IgM as a monomer can also do this)

IgE 

Extra rigid central domain

has the most carbohydrates

IgE primarily defends against parasitic invasion and is responsible for allergic reactions.

basophils and tissue mast cells express very high affinity Fc receptors for IgE - mast cells then release histamine

so high that almost all IgE is bound

sensitizes (activates) mucosal cells and tissues 

protects against helminth parasites

IgE’s main purpose is to protect against parasites but due to improved sanitation these are no longer a prevalent issue across most of the world. Consequently it is thought that they become over activated and over sensitive while looking for parasites and start reacting to eg pollen and causing allergies.

IgA

Exists in serum in both monomeric (IgA1) and dimeric (IgA2) forms (dimeric when 2 Fcs bind via secretory complex)

15% of the total serum Ig.

4-7 day half life

Secretory IgA2 (dimer) = primary defense against some local infections

Secreted as a dimer in mucous (e.g., saliva, tears)

prevents passage of foreign substances into the circulatory system

Isotype: class of antibody (IgD, IgM etc)

Allotype: person specific alleles 

Idiotype: (hyper) variable region - antibody specificity 

Strep throat.

12.3.17

When your teacher said they’re going to post a study guide but they don’t qq

Music mood: Rubber Human - Mili

I made a lymph drainage sticker for the immuno section of first aid

You can get the Sticker here: https://www.redbubble.com/people/histrionicole/works/29980305-lymph-node-drainage?asc=u&p=sticker

Biochem enzymes MNEMONIC

“ABC” enzymes

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“TLC For Nancy” (TLCFN) Coenzymes & Cofactors

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Thiamine PyroPhosphate -TPP- requiring enzymes (B1)

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Pirydoxine (B6) coenzyme

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Cyanocobalamine (B12) coenzyme

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Succynil CoA source: “VOMIT”

Stuff in my Office

From 1930. This well-dressed young scientist is experimenting with The Air. Exactly what he is doing is a mystery.

July 25 …. I finally get it!  He’s holding an eye dropper with a bulb on the end. I thought it was a pair of chopsticks! He’s picking up pieces of paper using the vacuum from squeezing the bulb! Still very formal, though …