Listeria With Tumbling Motility (by Pathmass)

Listeria with tumbling motility (by Pathmass)

Listeria monocytogenes

Gram+, aerobic, motile rod, facultative intracellular, beta hemolytic on blood agar

Tumbling motility in broth (as seen in video)

Jet motility in cells by actin filament formation

Listeriolysin O (Beta hemolysin): pathogenic factor, facilitates it scape from phagosome before phagolysosome formation and “jets” into another cell.

Diseases:

Lysteriosis: asymptomatic or diarrhea. 

Lysteriosis in pregnant women septicimia, crosses placenta.

Granulomatosis infantisepticum: neonatal disease, in utero transmission, sepsis, diseminated granulomas and high mortality.

Neonatal sepsis and meningitis (3° most common cause) 2-3 weeks after birth (fecal exposure)

Septicemia and meningitis in immunocompromised pts

Meningitis in renal transplant pts, cancer pts

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