Listeria with tumbling motility (by Pathmass)
Listeria monocytogenes
Gram+, aerobic, motile rod, facultative intracellular, beta hemolytic on blood agar
Tumbling motility in broth (as seen in video)
Jet motility in cells by actin filament formation
Listeriolysin O (Beta hemolysin): pathogenic factor, facilitates it scape from phagosome before phagolysosome formation and “jets” into another cell.
Diseases:
Lysteriosis: asymptomatic or diarrhea.
Lysteriosis in pregnant women septicimia, crosses placenta.
Granulomatosis infantisepticum: neonatal disease, in utero transmission, sepsis, diseminated granulomas and high mortality.
Neonatal sepsis and meningitis (3° most common cause) 2-3 weeks after birth (fecal exposure)
Septicemia and meningitis in immunocompromised pts
Meningitis in renal transplant pts, cancer pts
Horizontal gene transfer
Ketone bodies are produced in the liver and can be used as an energy source in the mitochondrial of peripheral tissues. Important fact: RBCs can not use ketones because they lack mitochondria.
The liver is unable to peform Ketolysis because it lacks Thiophorase (Succinyl-CoA Acetoacetate Transferase), and is hence unable to activate its own ketones.
nasty moodboard
Side effects of drugs commonly given to the elderly
For sleep aid do not give barbituates or diphenhydramine (1st gen antihistamine). Instead, give Ramelteon.
That cell specialization…it’s pretty important.
(From our video)
Microbiology Mnemonics
If you cannot grasp what I have just explained, you should just leave and study economics!
Microbiology professor, first lecture (via scienceprofessorquotes)
From 1930. This well-dressed young scientist is experimenting with The Air. Exactly what he is doing is a mystery.
July 25 …. I finally get it! He’s holding an eye dropper with a bulb on the end. I thought it was a pair of chopsticks! He’s picking up pieces of paper using the vacuum from squeezing the bulb! Still very formal, though …