Live, Attenuated Vaccines Available In The US

Tick-Borne Diseases

ETC shortcuts

FADH2 goes to complex II since 2 hydrogens

RotenONE inhibits complex ONE

AntImIcIn A, 3 III’s ==> Antimycin A inhibits complex 3

Cyan COlored Complex IV ==> Cyanide and CO inhibit complex IV

24 brown fatty aspirins break up ==> 2,4 dnp, aspirin and brown fat are etc uncouplers 

Diphtheria is known for creating a slimy/sticky/smelly exudate in the throat and mouth, but there are quite a few variations on its etiology and presentation.

A. Common type of diphtheria. Child three years old, seen on fourth day of illness. Exudate covering pharynx, tonsils, and uvula. Received 16,000 units of antitoxin. Throat clear on sixth day. Discharged cured.

B. Follicular type of diphtheria. Child seven years old, seen on second day of illness. The membrane involved the lacunae of the tonsils. Resembles follicular tonsillitis. Received 6,000 units of antitoxin total.

C. Hemorrhagic type of diphtheria. Child seven-and-a-half years old, seen on sixth day of illness. Tonsillar and post-pharyngeal exudate. Severe nasal and post-pharyngeal hemorrhages during exfoliation of membrane. Received in all 15,000 units of antitoxin. Throat clear on ninth day of illness. Myocarditis developed. Case discharged cured four weeks after admission. 

D. Septic type of diphtheria. Child eight years old, seen on fifth day of illness. The pseudo-membrane in this case covered the hard palate and extended in one large mass down the pharynx, completely hiding the tonsils.

Diseases of Infancy and Childhood. Louis Fischer, M.D., 1917.

Micobacterium tuberculosis DX

Auramine-Rhodamine staining bacilli: fluorescent apple green (sensitive but not specific). If positive, do acid fast.

Acid Fast

Lowenstein-Jensen medium: aerobic, slow growing (2-3weeks)

PPD or Mantoux Test: measure 48-72h after. POSITIVE: >/= 5mm in VIH+ pts, >/=10mm in high risk population (IVDA, poverty, immigrants from high TB area, physicians, nurses), >/=15mm in low risk population

Positive indicates exposure, but not necessarily active disease.

Quantiferon-TB Gold Test: measures IF-gamma

Niacin producers

Catalase negative at 68° and catalase active at body T°

No serodiagnosis

Medically Important Bacteria: Clasification

18/1/18 - Recent virology notes! Ignore the headings, I bought some new brush pens and I’m still getting used to them..

hey! could you do a study tips post on studying w friends who aren't doing the same subjects? like, how to make good flashcards/questions and answers etc so they can quiz you and give you hints etc even if they don't know the content?

How to Effectively Study with Friends

Using Flash Cards

Oh easy peasy! Simply write examination style questions on your flashcards - that way when your friends read the questions out to you, you’ll be testing yourself in a way that might show up on the easier exam questions. Reason being that in order to cover all the topics, your questions will tend to be somewhat simple e.g. describe the different components of x, explaining how they related to y. Obviously, flash cards aren’t the best way to study more complex interrelationships between ideas/concepts, which should be explored more in a mind map fashion. For tips on mind maps, you can check out my briefing here. 

Using Your Existing Study Notes

Other than flash cards, if you intend to study in groups for most subjects, one of the best ways to do that is to use the Cornell Notetaking System (which you can read about with my personal tips here). Writing the questions out as you study saves you the trouble of writing out questions for your friends to test you on, and as well as that, means you can test yourself almost as well without them for any times when you’re studying solitary. 

Using Essay or Long Response Questions

For long response essays, it’s better to use principles like the rubber duck method, i.e. explaining how concepts relate to each other as if the other person doesn’t know anything about it. So give your friends a list of essay questions and explain part by part in a logical sequential order how you would answer that question e.g. I would talk about the involvement of person A in event B, and explain their impact through examples C, D and E, etc. 

Choosing the Right Study Group 

Most of all, make sure you rally and encourage each other. Work with people who are like-minded, rotate between each other and have someone who will keep the others on task when you start getting too carried away when studying. Having a goal on what you intend to get finished during a group study session will make sure you always get more out of the session than studying alone!

Hope that helps! ^_^

Neisseria gonorrhoeae

PMN filled with Neisseria gonorrhoeae => Gram- diplococci, glucose fermenter, non maltose fermenter, oxidase positive.

Very inflammatory response: exudate with high number of PMN. TX with ceftriaxone and always ALWAYS test for Chlamydia trachomatis (since is more common and exudate is similar)

How to tell them apart? 

N. gonorrhoeae’s exudate is more purulent than C. trachomatis.

N. gonorrhoeae’s exudate is “greenish-yellowish” but C. trachomatis’s is whiter.

N. gonorrhoeae is always inside a PMN while C. trachomatis is not 

Grows in Thayer-Martin medium (chocolote agar + antibiotics, is a selective medium)

Yesterday’s notes featuring actual winter sunshine!!

A sample of notes from Medical Virology // I keep the margins empty so that I have space to add in relevant additional material from extra reading